| Torng PL |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=6.440 ------>paper_class3=2 ------>paper_class2=1 ------>vol=27 ------>confirm_bywho=cyhsu ------>insert_bywho=ycgl ------>Jurnal_Rank=10.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=2147 ------>medlineContent= ------>unit=E0700 ------>insert_date=20071114 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=0950-9232 ------>authors_c=??? ------>score=500 ------>journal_name=Oncogene ------>paper_name=Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma ------>confirm_date=20080901 ------>tch_id=092072 ------>pmid=17952116 ------>page1=2137 ------>fullAbstract=Metastasis and invasion occur in the majority of epithelial ovarian carcinoma at diagnosis. To delineate the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive activity). P4 showed faster migration and larger xenograft formation with metastasis than P0. By microarray analysis of different gene expression among P0-P4 sublines, one group of gene was found negatively correlated with cancer invasion. Among these genes, IGFBP-3 was identified as one of the most remarkably suppressed gene that showed lower gene expression in P4 than P0. Re-expression of IGFBP-3 in P4 effectively inhibited cell migration, invasion and metastasis, but did not affect cell proliferation. In 35 patients with EC tumors, low IGFBP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival. Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC. ------>tmu_sno=None ------>sno=16173 ------>authors2=Lee YCG ------>authors3=Huang CY ------>authors4=Ye JH ------>authors5=Lin YS ------>authors6=Chu YW, Huang SC, Cohen P, Wu CW, Lin CT ------>authors6_c= ------>authors=Torng PL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=15 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=4 |