Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Xu Q*
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------>insert_date=20071115
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------>journal_name=Endocrine
------>paper_name=Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells.
------>confirm_date=20081212
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------>pmid=17955388
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------>fullAbstract=Androgen and the androgen receptor (AR) have been shown to play critical roles in male fertility. Our previous data demonstrated that mice lacking AR (AR(-/y)) revealed incomplete germ cell development and lowered serum testosterone levels, which resulted in azoospermia and infertility. However, the consequences of AR loss in Leydig cells remain largely unknown. Using a Cre-LoxP conditional knockout strategy, we generated a tissue-specific knockout mouse (L-AR(-/y)) with the AR gene deleted by the anti-Mullerian hormone receptor-2 (Amhr2) promoter driven Cre expressed in Leydig cells. Phenotype analyses show that the outside appearance of L-AR(-/y) mice was indistinguishable from wild type mice (AR(+/y)), but with atrophied testes and epididymis. L-AR(-/y) mice were infertile, with spermatogenic arrest predominately at the round spermatid stage and no sperm could be detected in the epididymis. L-AR(-/y) mice also have lower serum testosterone concentrations and higher serum leuteinizing hormone and follicle-stimulating hormone concentrations than AR(+/y) mice. Further mechanistic studies demonstrated that hypotestosteronemia in L-AR(-/y) mice is not caused by reducing numbers of Leydig cells, but instead by the alterations of several key steroidogenic enzymes, including 17beta-HSD3, 3beta-HSD6, and P450c17. Together, L-AR(-/y) mice provide in vivo evidence that functional AR in Leydig cells is essential to maintain normal spermatogenesis, testosterone production, and required for normal male fertility.
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------>authors2=Lin HY*
------>authors3=Yeh SD*
------>authors4=Yu IC
------>authors5=Wang RS
------>authors6=Chen YT,Zhang C,Altuwaijri S,Chen LM, Chuang KH, C
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------>authors=Xu Q*
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------>updateTitle=Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells.
------>language=2
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------>publish_year=2007
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------>publish_month=10
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z