| Chang SL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.708 ------>paper_class3=2 ------>paper_class2=1 ------>vol=93 ------>confirm_bywho=yjchen ------>insert_bywho=yjchen ------>Jurnal_Rank=14.9 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=88 ------>medlineContent= ------>unit=E1400 ------>insert_date=20071122 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Heart ------>paper_name=Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. ------>confirm_date=20090501 ------>tch_id=087031 ------>pmid=16905626 ------>page1=82 ------>fullAbstract=BACKGROUND: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. OBJECTIVE: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. METHODS: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. RESULTS: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p<0.05), mean (standard deviation (SD)) firing rates of spontaneous activity (1.7 (0.2), 2.1 (0.3) and 3 (0.2) Hz; p<0.05) and incidence of early post-depolarisations (9%, 26% and 61%; p<0.05) and delayed post-depolarisations (0%, 4% and 30%; p<0.05) in 23 pulmonary veins. In the seven preparations with spontaneous activity after the 300-mg stretch, gadolinium (1, 3 and 10 mumol/l) decreased the incidence of spontaneous activity by 43%, 29% and 14%, respectively (p<0.05), and decreased the firing rate from 2.9 (0.1) Hz to 0.8 (0.4), 0.3 (0.1) and 0.1 (0.1) Hz, respectively (p<0.05). Streptomycin (10 and 40 mumol/l) decreased the incidence of spontaneous activity by 71% and 29%, respectively (p<0.05), and decreased the firing rate from 2.9 (0.1) Hz to 1.6 (0.4) and 0.5 (0.3) Hz, respectively (p<0.05). CONCLUSION: Stretch is an important factor in the electrical activity of the pulmonary vein. Stretch-induced arrhythmogenic activity of the pulmonary vein may contribute to the genesis of atrial fibrillation. ------>tmu_sno=None ------>sno=16233 ------>authors2=Chen YC ------>authors3=Chen YJ ------>authors4=Wangcharoen W ------>authors5=Lee SH ------>authors6=Lin CI, Chen SA ------>authors6_c= ------>authors=Chang SL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=5 |