| Wang SC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.010 ------>paper_class3=2 ------>paper_class2=1 ------>vol=34 ------>confirm_bywho=shiemin ------>insert_bywho=chaurjongh ------>Jurnal_Rank=31.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=725 ------>medlineContent= ------>unit=E0123 ------>insert_date=20071123 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J Rheumatol ------>paper_name=Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus ------>confirm_date=20080502 ------>tch_id=093052 ------>pmid=17343323 ------>page1=721 ------>fullAbstract=OBJECTIVE: To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). METHODS: One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. RESULTS: The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. CONCLUSION: PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan. ------>tmu_sno=None ------>sno=16242 ------>authors2=Lin CH ------>authors3=Ou TT ------>authors4=Wu CC ------>authors5=Tsai WC ------>authors6=Hu CJ, Liu HW, Yen JH ------>authors6_c= ------>authors=Wang SC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |