| Lee JM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.391 ------>paper_class3=2 ------>paper_class2=1 ------>vol=38 ------>confirm_bywho=shiemin ------>insert_bywho=hsuc ------>Jurnal_Rank=13.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=29 ------>paper_class2Letter=None ------>page2=3291 ------>medlineContent= ------>unit=E0100 ------>insert_date=20071129 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1524-4628 ------>authors_c= ------>score=500 ------>journal_name=Stroke ------>paper_name=Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive Rats ------>confirm_date=20071201 ------>tch_id=091141 ------>pmid=17962594 ------>page1=3289 ------>fullAbstract=BACKGROUND AND PURPOSE: Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS: Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS: Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS: Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak. ------>tmu_sno=None ------>sno=16302 ------>authors2=Zhai GH ------>authors3=Liu QW ------>authors4=Chang LS ------>authors5=Yin KJ ------>authors6=Yan P, Hsu CY, Vo K, Lin WL ------>authors6_c= ------>authors=Lee JM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=12 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=10 |