| Chen LG |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.186 ------>paper_class3=2 ------>paper_class2=1 ------>vol=46 ------>confirm_bywho=amel ------>insert_bywho=crystal ------>Jurnal_Rank=13.6 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=693 ------>medlineContent= ------>unit=G0100 ------>insert_date=20071210 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Food and Chemical Toxicology ------>paper_name=Anti-inflammatory activity of mangostins from Garcinia mangostana ------>confirm_date=20081204 ------>tch_id=088003 ------>pmid=18029076 ------>page1=688 ------>fullAbstract=The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G. mangostana, and both significantly inhibited nitric oxide (NO) and PGE(2) production from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC(50) values for the inhibition of NO production by alpha- and gamma-mangostins were 12.4 and 10.1 microM, respectively. After iNOS enzyme activity was stimulated by LPS for 12 h, treatment with either alpha- or gamma-mangostin at 5 microg/ml (12.2 and 12.6 microM, respectively) for 24 h did not significantly inhibit NO production. The data show that the inhibitory activities of alpha- and gamma-mangostins are not due to direct inhibition of iNOS enzyme activity. On the other hand, expression of iNOS was inhibited by alpha- and gamma-mangostins in LPS-stimulated RAW 264.7 cells, but not by COX-2. However, the level of PGE(2) production was reduced by the two xanthones. In an in vivo study, alpha-mangostin significantly inhibited mice carrageenan-induced paw edema. In conclusion, alpha- and gamma-mangostins from G. mangostana are bioactive substances with anti-inflammatory effects. ------>tmu_sno=None ------>sno=16399 ------>authors2=Yang LL ------>authors3=Wang CC ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chen LG ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Anti-inflammatory activity of mangostins from Garcinia mangostana. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=2 |