Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Lee HH,
------>authors3_c=
------>paper_class1=1
------>Impact_Factor=1.995
------>paper_class3=2
------>paper_class2=2
------>vol=14
------>confirm_bywho=None
------>insert_bywho=llyang
------>Jurnal_Rank=51.4
------>authors4_c=
------>comm_author=1
------>patent_EDate=None
------>authors5_c=
------>publish_day=1
------>paper_class2Letter=None
------>page2=827
------>medlineContent=
------>unit=G0100
------>insert_date=20071211
------>iam=3
------>update_date=None
------>author=???
------>change_event=6
------>ISSN=
------>authors_c=
------>score=500
------>journal_name=.J Biomed Sci.
------>paper_name=Neuroprotection and free radical scavenging effects of Osmanthus fragrans.
------>confirm_date=None
------>tch_id=058001
------>pmid=17846921
------>page1=819
------>fullAbstract=The ethanol extract of dried flowers Osmanthus fragrans (OFE) was assessed for free radical scavenging effects measured by the bleaching of the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, scavenging of the hydroxyl anion, investigation of the ferric reducing/antioxidant power (FRAP) and lipid-peroxidation inhibition in rat tissues. OFE contained a high amount of total flavonoid and polyphenol. OFE presented the effects in the metal reducing power, FRAP assay with IC(50) values of 0.23 microg/ml, and 7.74 microg/ml, respectively. OFE presented similar activities toward the DPPH and hydroxyl anion scavenging ability with IC(50) values of 10 microg/ml. OFE with IC(50 )values between 46 and 97 microg/ml inhibited lipid peroxidation initiated by ferrous chloride in rat brain, liver, heart and kidney mitochodrias. Moreover, the neuroprotective activity of OFE was investigated under different insults (glutamate, arachidonic acid, and 6-hydroxydopamine) in Wistar rat primary cortical neurons. OFE with EC(50 )values between 66 and 165 microg/ml attenuated the neurotoxicity on MTT and LDH assays. In addition, the AKT protein expression of excitotoxicity and oxidative stress was displayed by western blotting analysis. OFE could up-regulate the glutamate and 6-OHDA decreased AKT expression. This is the first demonstration of the neuroprotective, free radical scavenging and anti-oxidative effects of O. fragrans.
------>tmu_sno=None
------>sno=16403
------>authors2=Lin CT,
------>authors3=Yang LL
------>authors4=
------>authors5=
------>authors6=
------>authors6_c=
------>authors=Lee HH,
------>delete_flag=0
------>SCI_JNo=None
------>authors2_c=
------>publish_area=0
------>updateTitle=Neuroprotection and free radical scavenging effects of Osmanthus fragrans.
------>language=2
------>check_flag=None
------>submit_date=None
------>country=None
------>no=6
------>patent_SDate=None
------>update_bywho=None
------>publish_year=2007
------>submit_flag=None
------>publish_month=12
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z