Lee HH, |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.995 ------>paper_class3=2 ------>paper_class2=2 ------>vol=14 ------>confirm_bywho=None ------>insert_bywho=llyang ------>Jurnal_Rank=51.4 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=827 ------>medlineContent= ------>unit=G0100 ------>insert_date=20071211 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=6 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=.J Biomed Sci. ------>paper_name=Neuroprotection and free radical scavenging effects of Osmanthus fragrans. ------>confirm_date=None ------>tch_id=058001 ------>pmid=17846921 ------>page1=819 ------>fullAbstract=The ethanol extract of dried flowers Osmanthus fragrans (OFE) was assessed for free radical scavenging effects measured by the bleaching of the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, scavenging of the hydroxyl anion, investigation of the ferric reducing/antioxidant power (FRAP) and lipid-peroxidation inhibition in rat tissues. OFE contained a high amount of total flavonoid and polyphenol. OFE presented the effects in the metal reducing power, FRAP assay with IC(50) values of 0.23 microg/ml, and 7.74 microg/ml, respectively. OFE presented similar activities toward the DPPH and hydroxyl anion scavenging ability with IC(50) values of 10 microg/ml. OFE with IC(50 )values between 46 and 97 microg/ml inhibited lipid peroxidation initiated by ferrous chloride in rat brain, liver, heart and kidney mitochodrias. Moreover, the neuroprotective activity of OFE was investigated under different insults (glutamate, arachidonic acid, and 6-hydroxydopamine) in Wistar rat primary cortical neurons. OFE with EC(50 )values between 66 and 165 microg/ml attenuated the neurotoxicity on MTT and LDH assays. In addition, the AKT protein expression of excitotoxicity and oxidative stress was displayed by western blotting analysis. OFE could up-regulate the glutamate and 6-OHDA decreased AKT expression. This is the first demonstration of the neuroprotective, free radical scavenging and anti-oxidative effects of O. fragrans. ------>tmu_sno=None ------>sno=16403 ------>authors2=Lin CT, ------>authors3=Yang LL ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lee HH, ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Neuroprotection and free radical scavenging effects of Osmanthus fragrans. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=12 |