| Liu, Z.-J., Sun, Y.-J., Rose, J., Chung, Y.-J., Hsiao, C.-D., W.-R., Kuo, I., Perozich, J., Lindahl, R., Hempel, J. and B. C. Wang |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=4 ------>confirm_bywho= ------>insert_bywho=cmbsun ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=326 ------>medlineContent= ------>unit=000 ------>insert_date=20000603 ------>iam=2 ------>update_date= ------>author=Sun,Y.-J. ------>change_event=1 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Nature Structural Biology ------>paper_name=The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold. ------>confirm_date= ------>tch_id= ------>pmid=9095201 ------>page1=317 ------>fullAbstract=The first structure of an aldehyde dehydrogenase (ALDH) is described at 2.6 A resolution. Each subunit of the dimeric enzyme contains an NAD-binding domain, a catalytic domain and a bridging domain. At the interface of these domains is a 15 A long funnel-shaped passage with a 6 x 12 A opening leading to a putative catalytic pocket. A new mode of NAD binding, which differs substantially from the classic beta-alpha-beta binding mode associated with the ~Rossmann fold~, is observed which we term the beta-alpha,beta mode. Sequence comparisons of the class 3 ALDH with other ALDHs indicate a similar polypeptide fold, novel NAD-binding mode and catalytic site for this family. A mechanism for enzymatic specificity and activity is postulated. ------>tmu_sno=None ------>sno=1646 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Liu, Z.-J., Sun, Y.-J., Rose, J., Chung, Y.-J., Hsiao, C.-D., W.-R., Kuo, I., Perozich, J., Lindahl, R., Hempel, J. and B. C. Wang ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho= ------>publish_year=1997 ------>submit_flag= ------>publish_month=None |