| Cheng YC |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.483 ------>paper_class3=2 ------>paper_class2=1 ------>vol=31 ------>confirm_bywho=yjchen ------>insert_bywho=liuxx086 ------>Jurnal_Rank=47.2 ------>authors4_c=??? ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1411 ------>medlineContent= ------>unit=E1400 ------>insert_date=20071217 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Leukemia Research ------>paper_name=Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia ------>confirm_date=20090318 ------>tch_id=091065 ------>pmid=17445886 ------>page1=1403 ------>fullAbstract=Valproic acid (VPA), an agent used for neurological disorders, has been shown to be a novel class of histone deacetylase inhibitor (HDACI), able to induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). In this study, we examined the underlying mechanisms in VPA-mediated activities in AML cells. VPA not only inhibited the growth of HL-60, U937 and NB4 cells by causing cell-cycle arrest at G(0)/G(1) phase and apoptosis, but also induced morphologic and phenotypic changes. VPA markedly increased p21WAF1, and downregulated c-Myc expression at transcriptional levels. Ectopic expression of wildtype c-Myc and T58A mutant significantly inhibited VPA-mediated growth inhibition. As with results from cell line studies, VPA also downregulated c-Myc levels, and induced apoptosis and myeloid differentiation of primary AML cells, leading to decreased colony-forming ability. Given the role of c-Myc in leukemogenesis, our study suggests that VPA might be a potential therapeutic agent for AML. ------>tmu_sno=None ------>sno=16472 ------>authors2=Lin H ------>authors3=Huang MJ ------>authors4=Chow JM ------>authors5=Lin S ------>authors6=Liu HE ------>authors6_c=??? ------>authors=Cheng YC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=11 |