Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Lin SJ
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------>journal_name=The 234th ACS National Meeting, Aug. 19-23, Boston, CA.
------>paper_name=Synthesis and SAR of 4-(benzylideneamino)benzenesulfonamides as selective COX-2 inhibitors
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------>fullAbstract=Two series of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamide derivatives were designed and synthesized for the evaluation as selective cyclooxygenase-2 (COX-2) inhibitors in a cellular assay using human whole blood (HWB). Extensive structure-activity relationships (SAR) were studied within these series. Several compounds were found to be novel and selective COX-2 inhibitors. Among them, the most potent and selective was 4-(3-carboxy-4-hydroxy-benzylideneamino)benzenesulfonamide (20, LA2135), (IC(50)~s for COX-1: 85.13 microM; COX-2: 0.74 microM; SI: 114.5), being more active COX-2 selective than celecoxib.
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------>authors2=Yang LM
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------>authors=Lin SJ
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------>updateTitle=Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides.
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------>publish_year=2007
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z