| Wen CC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.115 ------>paper_class3=2 ------>paper_class2=1 ------>vol=50 ------>confirm_bywho=amel ------>insert_bywho=cklee ------>Jurnal_Rank=11.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=4095 ------>medlineContent= ------>unit=G0100 ------>insert_date=20071220 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=400 ------>journal_name=J. Med. Chem. ------>paper_name=Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute ------>confirm_date=20071221 ------>tch_id=091116 ------>pmid=17663539 ------>page1=4087 ------>fullAbstract=In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects. ------>tmu_sno=None ------>sno=16539 ------>authors2=Kuo YH ------>authors3=Jan JT ------>authors4=Liang PH ------>authors5=Wang SY ------>authors6=Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, ------>authors6_c= ------>authors=Wen CC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |