| Tsao CW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.769 ------>paper_class3=2 ------>paper_class2=1 ------>vol=30 ------>confirm_bywho=hychiou ------>insert_bywho=baich ------>Jurnal_Rank=21.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=905 ------>medlineContent= ------>unit=J0200 ------>insert_date=20080312 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Progress in Neuropsychopharmacology and Biological Psychiatry ------>paper_name=Cytokines and serotonin transporter in patients with major depression ------>confirm_date=20080313 ------>tch_id=094128 ------>pmid=16616982 ------>page1=899 ------>fullAbstract=Altered cytokine secretion as a mechanism in the etiology of depression is still obscure. The serotonin transporter (5-HTT) may play an important role in the termination of serotonergic neurotransmission by serotonin (5-HT) uptaking into presynaptic neurons and representing as an initial action site for selective 5-HTT reuptake inhibitors (SSRI). In our study, we evaluated whether cytokines and 5-HTT acted as biological markers for depression. Blood samples were collected from 42 participants. The differences in cytokine and 5-HTT mRNA expressions of leukocytes were assessed between the patients with major depression (n=20) and the healthy controls (n=22), along with the measurements prior and after treatment with a SSRI, fluoxetine, for 3 months in the follow-up patient group (n=8). The results revealed that the mRNA expressions of IL-1beta, IL-6, IFNgamma, TNFalpha, and 5-HTT were higher in the depressed patients than those of the healthy controls. The higher level of mRNA expressions of IFNgamma and 5-HTT diminished after fluoxetine treatment. Furthermore, we found a positive correlation between 5-HTT and cytokines mRNA expressions in total participants, which suggested that pro-inflammatory cytokines and 5-HTT might play critical roles in the pathogenesis of major depression and that their levels were affected by chronic treatment with 5-HTT inhibitors. ------>tmu_sno=None ------>sno=16700 ------>authors2=Lin YS ------>authors3=Chen CC ------>authors4=Bai CH ------>authors5=Wu SR ------>authors6= ------>authors6_c= ------>authors=Tsao CW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Cytokines and serotonin transporter in patients with major depression. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=7 |