| Lin YL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=4.128 ------>paper_class3=2 ------>paper_class2=1 ------>vol=82 ------>confirm_bywho=leehorng ------>insert_bywho=ycliang ------>Jurnal_Rank=21.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1480 ------>medlineContent= ------>unit=E0310 ------>insert_date=20080315 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J. Leukoc. Biol. ------>paper_name=Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. ------>confirm_date=20080801 ------>tch_id=089135 ------>pmid=17761954 ------>page1=1473 ------>fullAbstract=Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family and represents a key regulator of angiogenic events in development and pathologic conditions. In this study, PlGF-modulated differentiation and maturation of human dendritic cells (DCs) from CD14+ monocytes were investigated. The DC, differentiated from CD14+ monocytes in the presence of PlGF during 5 days, was referred to as "PlGF-DC", in contrast to the "classical-DC", obtained in the absence of PlGF. Treatment of PlGF-DC or classical-DC with PlGF resulted in the down-regulation of CD80, CD86, CD83, CD40, and HLA-DR expression, and CD1a was increased, as well as the inhibition of IL-12 p70, p40, IL-8, and TNF-alpha production in response to LPS stimulation. This PlGF-induced DC dysfunction was recovered by anti-human VEGF receptor 1 mAb. In addition, treatment of PlGF-DC or classical-DC with PlGF resulted in the suppression of naive CD4+ T cell proliferation in an allogenic MLR but up-regulated the IL-5 and IL-13 secretion of the CD4+ T cell. PlGF was also able to inhibit LPS-induced IkappaBalpha phosphorylation and NF-kappaB activity. Taken together, our data demonstrate that the immunosuppressive properties of PlGF are through the NF-kappaB signaling pathway. PlGF might play a major role in the pathogenesis of tumors and act as an effector molecule to skew T cell response to the Th2 phenotype, which might be more beneficial for pregnancy. ------>tmu_sno=None ------>sno=16828 ------>authors2=Liang YC ------>authors3=Chiang BL ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lin YL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |