| HC Kau |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.867 ------>paper_class3=2 ------>paper_class2=1 ------>vol=18 ------>confirm_bywho=None ------>insert_bywho=wmhsu ------>Jurnal_Rank=31.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=639 ------>medlineContent= ------>unit=000 ------>insert_date=20080320 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Eye ------>paper_name=Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. ------>confirm_date=None ------>tch_id=096076 ------>pmid=14716324 ------>page1=635 ------>fullAbstract=PURPOSE: Ultraviolet irradiation is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium. The highly mutagenic 8-hydroxy-2~-deoxyguanosine, a marker for the evaluation of photo-oxidative DNA damage, can be repaired by human 8-oxoguanine glycosylase I (hOGG1). A transition of C to G at nucleotide position 1245 in exon 7 of the hOGG1 gene is associated with the substitution of cysteine for serine at codon 326. In this study, we investigated the association of the hOGG1 Ser326Cys polymorphism with pterygium in a Chinese population. METHODS: In all, 70 patients and 86 controls were enrolled in this study. The Ser326Cys polymorphism was determined by the polymerase chain reaction-restriction fragment-length polymorphism analysis. The association between this genetic polymorphism and risk of pterygium was examined by chi(2)-test and logistic regression. RESULTS: The allelic frequencies for the Ser and Cys variants of hOGG1 gene were not significantly different between the two groups. However, when compared with Ser/Ser and Ser/Cys genotypes combined, we found that the homozygous Cys/Cys genotype was more prevalent in pterygium patients than controls (P=0.024) with the odds ratio being 2.2 (95% CI: 1.1-4.5). In the pterygium group, the mean age of patients with the Cys/Cys genotype was younger than those with the other two genotypes (P=0.025). CONCLUSIONS: Our findings suggest that the 1245C --> G transition in exon 7 of the hOGG1 gene, which results in Ser326Cys substitution of the enzyme, might play a role in the susceptibility of humans to pterygium. ------>tmu_sno=None ------>sno=16985 ------>authors2=CC Tsai ------>authors3=WM Hsu ------>authors4=JH Liu ------>authors5=YH Wei ------>authors6= ------>authors6_c= ------>authors=HC Kau ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=1 |