Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Kesten SJ
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------>journal_name=J. Med. Chem.
------>paper_name=Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures.
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------>fullAbstract=To improve upon the activity and properties of the 3-aryl-7-chloro-3,4- dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained. The [3-(N,N- dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)- acridinedione (9aa) proved to be highly active in advanced studies in primates.
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------>authors2=Degnan MJ
------>authors3=Hung Wang JHP
------>authors4=McNamara DJ
------>authors5=Ortwine DF
------>authors6=Uhlendorf SE, Werbel LM
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------>authors=Kesten SJ
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------>updateTitle=Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures.
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------>publish_year=1992
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z