Kesten SJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=4.926 ------>paper_class3=2 ------>paper_class2=1 ------>vol=35 ------>confirm_bywho=amel ------>insert_bywho=hpw ------>Jurnal_Rank=8.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=3447 ------>medlineContent= ------>unit=G0100 ------>insert_date=20080321 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J. Med. Chem. ------>paper_name=Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures. ------>confirm_date=20080506 ------>tch_id=096021 ------>pmid=1404226 ------>page1=3429 ------>fullAbstract=To improve upon the activity and properties of the 3-aryl-7-chloro-3,4- dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained. The [3-(N,N- dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)- acridinedione (9aa) proved to be highly active in advanced studies in primates. ------>tmu_sno=None ------>sno=17062 ------>authors2=Degnan MJ ------>authors3=Hung Wang JHP ------>authors4=McNamara DJ ------>authors5=Ortwine DF ------>authors6=Uhlendorf SE, Werbel LM ------>authors6_c= ------>authors=Kesten SJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=1992 ------>submit_flag=None ------>publish_month=1 |