| Huang YK |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=4.115 ------>paper_class3=2 ------>paper_class2=1 ------>vol=98 ------>confirm_bywho=None ------>insert_bywho=morri ------>Jurnal_Rank=26.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=11 ------>paper_class2Letter=None ------>page2=869 ------>medlineContent= ------>unit=E0111 ------>insert_date=20080321 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Br J Cancer ------>paper_name=Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening ------>confirm_date=None ------>tch_id=067013 ------>pmid=18283313 ------>page1=863 ------>fullAbstract=Knowing that infection of high-risk human papillomavirus (HPV) causes virtually all cervical cancer (CC), the long-term outcomes of HPV infection, especially the absolute risk and time lapse of developing CC, are beyond the scope of ordinary follow-up study owing to ethical concerns. The present study followed the natural history and long-term outcomes of HPV infection in a cohort of women by national health insurance care and data linkage without additional disturbance. The status of cervical HPV infection was determined in 1708 healthy women, aged 20-90 (median 43), enrolled from 10 hospitals in seven cities around the island country of Taiwan. Records of consecutive Pap smear results and cancer reports of 108 cytology-negative, HPV-positive and 1202 cytology- and HPV-negative women with no prior record of CC or abnormal cervical cytology were retrospectively analysed for a duration of up to 75 months (median 61 months). The cumulative incidences of high-grade squamous intraepithelial lesion (HSIL) and in situ/invasive cancer in HPV-positive women were 5.6 and 3.7%, respectively, and those in HPV-negative women were 0.3 and 0%. After adjusting for other risk factors, HPV-positive subjects had 24.9 (95% CI: 7.0-108.3; P<0.0001) folds of risk of developing HSIL or above cervical neoplasia as compared to HPV-negative subjects, whereas risk for low-grade intraepithelial lesion and atypical squamous cytology was not increased. The study showed that women with a prevalent infection of high-risk HPV had a 4% cumulative risk for CC in 6 years, whereas those tested negative had little risk. The result supports an HPV test-orientated CC screening programme with intervals of at least 5 years. ------>tmu_sno=None ------>sno=17130 ------>authors2=You SL ------>authors3=Yuan CC ------>authors4=Ke YM ------>authors5=Cao LM ------>authors6=Liao CY,Wu CH,Hsu CS, Huang KF, Lu CH, Twu NF, Chu ------>authors6_c=??? ------>authors=Huang YK ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=3 |