| Chen SH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.393 ------>paper_class3=2 ------>paper_class2=1 ------>vol=45 ------>confirm_bywho=jschu ------>insert_bywho=ccllfang ------>Jurnal_Rank=7.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=2303 ------>medlineContent= ------>unit=E0102 ------>insert_date=20080323 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Food Chem Toxicol. ------>paper_name=Aloe-emodin-induced apoptosis in human gastric carcinoma cells ------>confirm_date=20080324 ------>tch_id=083010 ------>pmid=17637488 ------>page1=2296 ------>fullAbstract=The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner. Noteworthy is that the AGS cells were generally more sensitive than the NCI-N87 cells. Aloe-emodin caused the release of apoptosis-inducing factor and cytochrome c from mitochondria, followed by the activation of caspase-3, leading to nuclear shrinkage and apoptosis. In addition, exposure to aloe-emodin suppressed the casein kinase II activity in a time-dependent manner and was accompanied by a reduced phosphorylation of Bid, a downstream substrate of casein kinase II and a pro-apoptotic molecule. These preclinical studies suggest that aloe-emodin represents a suitable and novel chemotherapeutic drug candidate for the treatment of human gastric carcinoma. ------>tmu_sno=None ------>sno=17139 ------>authors2=Lin KY ------>authors3=Chang CC ------>authors4=Fang CL ------>authors5=Lin CP ------>authors6= ------>authors6_c= ------>authors=Chen SH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Aloe-emodin-induced apoptosis in human gastric carcinoma cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=11 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |