Lee O |
------>authors3_c= ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol= ------>confirm_bywho=amel ------>insert_bywho=hpw ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=G0100 ------>insert_date=20080324 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=146 ------>journal_name=Abst. 1999 PSCT Med. Chem. Sym. ------>paper_name=Selective cytotoxicity of novel Azatyrosinamides. ------>confirm_date=20081217 ------>tch_id=096021 ------>pmid=16039850 ------>page1=39 ------>fullAbstract=This study aims to develop novel azatyrosinamide compounds structurally modified from ras-specific antioncogenic azatyrosine. Analogues 4-15 were prepared and their inhibition on the growth of wild-type and ras-transformed NIH 3T3 cell lines was compared. Compound 12 was found to be the most active with IC50 16.5+/-2.2 microM which is 458-fold more potent than that of azatyrosine. The selective toxicity, defined as IC(50 wild-type)/IC(50 ras-transformed) for this compound was 138.5. ------>tmu_sno=None ------>sno=17312 ------>authors2=Li YI ------>authors3=Hwang CF ------>authors4=Wang HP ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lee O ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=2 ------>updateTitle=Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=NULL ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=1999 ------>submit_flag=None ------>publish_month=1 |