Wang KH |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.309 ------>paper_class3=2 ------>paper_class2=5 ------>vol=30 ------>confirm_bywho=shiemin ------>insert_bywho=khwang ------>Jurnal_Rank=15.2 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=445 ------>medlineContent= ------>unit=E0118 ------>insert_date=20080325 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1076-0512 ------>authors_c=??? ------>score=500 ------>journal_name=Dermatologic Surgery ------>paper_name=Erbium:YAG laser pretreatment accelerates the response of Bowen's disease treated by topical 5-fluorouracil. ------>confirm_date=20080502 ------>tch_id=093019 ------>pmid=15008880 ------>page1=441 ------>fullAbstract=BACKGROUND: Topical 5-fluorouracil (5-FU) is a standard treatment for Bowen~s disease. However, its efficacy may be limited by the presence of stratum corneum. The Er:YAG laser has shown a dramatic enhancement effect on the delivery of 5-FU in vitro by ablation of the stratum corneum. The efficacy of laser-assisted delivery of 5-FU has not been tested in human. OBJECTIVE: To see whether Er:YAG laser pretreatment can improve the efficacy of topical 5-FU in the treatment of Bowen~s disease. METHODS: Three target lesions from a patient with multiple Bowen~s disease were selected for a half-side comparison study. The Er:YAG laser was used to remove the cornified layer on one side of each lesion, followed by twice-daily application of 5-FU cream to both sides. Clinical and histologic responses were compared. RESULTS: Lesions pretreated with the Er:YAG laser showed more rapid clinical and histologic responses to topical 5-FU than those treated with 5-FU alone. Evaluation at 9 months after treatment showed no recurrences of lesions on both sides. CONCLUSIONS: Our preliminary study demonstrates that this Er:YAG laser-assisted modality is effective and shows accelerated clinical response and shortened treatment time compared with topical 5-FU as a single treatment. ------>tmu_sno=None ------>sno=17367 ------>authors2=Fang JY ------>authors3=Hu CH ------>authors4=Lee WR ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Wang KH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Erbium:YAG laser pretreatment accelerates the response of Bowen~s disease treated by topical 5-fluorouracil. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=3 |