| Wu LT |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.553 ------>paper_class3=2 ------>paper_class2=1 ------>vol=54 ------>confirm_bywho=chshih43 ------>insert_bywho=kuochen101 ------>Jurnal_Rank=38.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=90 ------>medlineContent= ------>unit=E0400 ------>insert_date=20080417 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=471 ------>journal_name=Diagn Microbiol Infect Dis ------>paper_name=issemination of Proteus mirabilis isolates harboring CTX-M-14 and CTX-M-3?-lactamases at 2 hospitals in Taiwan ------>confirm_date=20080418 ------>tch_id=096016 ------>pmid=16406185 ------>page1=89 ------>fullAbstract=From February to June 2003, 111 clinical isolates of Proteus mirabilis were mainly isolated from patients with respiratory or urinary tract infections hospitalized at 3 district hospitals (A, B, C) in central Taiwan. Among them, 34 (30.6%) strains, isolated within 2 hospitals (A and B), exhibited nonsusceptibility to cefotaxime with significant reduction of MIC (> or = 3 log2 dilution) by the effect of clavulanic acid, which confirmed the phenotype of extended-spectrum beta-lactamases (ESBLs). These ESBL producers were coresistant to gentamicin, isepamicin, and amikacin, but remained susceptible to ceftazidime (MIC, < or = 0.5 microg/mL) and meropenem (MIC, <0.5 microg/mL). By isoelectric focusing analysis, polymerase chain reaction, and nucleotide sequencing, we detected the presence of CTX-M-14 in 33 strains and CTX-M-3 in 6 strains (5 strains harboring both CTX-M-14 and CTX-M-3 enzymes). These beta-lactamase genes can be successfully transferred by the conjugative plasmid. Molecular epidemiology of the 34 ESBL-producing P. mirabilis strains by pulsed-field gel electrophoresis using SfiI restriction enzyme revealed 9 different genotypes, suggesting epidemic clones with intra- and interhospital spread. In conclusion, the broadly extended clonal spreading of CTX-M-type P. mirabilis was first discovered at the district hospitals in Taiwan. ------>tmu_sno=None ------>sno=17592 ------>authors2=Wu HC ------>authors3=Chung JG ------>authors4=Chuang YC ------>authors5=Cheng KC ------>authors6=Yu WL ------>authors6_c= ------>authors=Wu LT ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Dissemination of Proteus mirabilis isolates harboring CTX-M-14 and CTX-M-3 beta-lactamases at 2 hospitals in Taiwan. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |