Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen YW
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------>insert_date=20080418
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------>journal_name=Anesth Analg
------>paper_name=Dextromethorphan and Dextrorphan Have Local Anesthetic Effect on Infiltrative Cutaneous Analgesia in Rats.
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------>fullAbstract=BACKGROUND: Dextromethorphan blocks sodium channels, the site of action of local anesthetics. In this study we evaluated whether dextromethorphan has a local anesthetic effect. METHODS: We administered dextromethorphan and its active metabolite--dextrorphan, and lidocaine subcutaneously to rats and tested them for cutaneous anesthesia. Drug-drug interactions and systemic safety indices (LD50s/ED50s) were also evaluated. RESULTS: Dextromethorphan and dextrorphan had a local anesthetic effect after cutaneous infiltration. The ranking of potencies was dextromethorphan > dextrorphan > lidocaine (P < 0.01 for each comparison). A combination of dextromethorphan or dextrorphan with lidocaine produced an additive effect. Dextromethorphan and dextrorphan had 2.4- and 1.9-fold higher system safety indices than did lidocaine. CONCLUSION: Dextromethorphan and dextrorphan were more potent local anesthetics than lidocaine, but with higher systemic safety indices. Coadministration of dextromethorphan or dextrorphan with lidocaine produced an additive effect.
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------>authors2=Chu KS
------>authors3=Lin CN
------>authors4=Tzeng JI
------>authors5=Lin MT
------>authors6=Chu CC, Wang JJ
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------>authors=Chen YW
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------>updateTitle=Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.
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------>publish_year=2007
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------>publish_month=5
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z