Chen YW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.131 ------>paper_class3=2 ------>paper_class2=1 ------>vol=104 ------>confirm_bywho=tlc ------>insert_bywho=jitzeng ------>Jurnal_Rank=32.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1255 ------>medlineContent= ------>unit=000 ------>insert_date=20080418 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=402 ------>journal_name=Anesth Analg ------>paper_name=Dextromethorphan and Dextrorphan Have Local Anesthetic Effect on Infiltrative Cutaneous Analgesia in Rats. ------>confirm_date=20080421 ------>tch_id=094011 ------>pmid=17456682 ------>page1=1251 ------>fullAbstract=BACKGROUND: Dextromethorphan blocks sodium channels, the site of action of local anesthetics. In this study we evaluated whether dextromethorphan has a local anesthetic effect. METHODS: We administered dextromethorphan and its active metabolite--dextrorphan, and lidocaine subcutaneously to rats and tested them for cutaneous anesthesia. Drug-drug interactions and systemic safety indices (LD50s/ED50s) were also evaluated. RESULTS: Dextromethorphan and dextrorphan had a local anesthetic effect after cutaneous infiltration. The ranking of potencies was dextromethorphan > dextrorphan > lidocaine (P < 0.01 for each comparison). A combination of dextromethorphan or dextrorphan with lidocaine produced an additive effect. Dextromethorphan and dextrorphan had 2.4- and 1.9-fold higher system safety indices than did lidocaine. CONCLUSION: Dextromethorphan and dextrorphan were more potent local anesthetics than lidocaine, but with higher systemic safety indices. Coadministration of dextromethorphan or dextrorphan with lidocaine produced an additive effect. ------>tmu_sno=None ------>sno=17664 ------>authors2=Chu KS ------>authors3=Lin CN ------>authors4=Tzeng JI ------>authors5=Lin MT ------>authors6=Chu CC, Wang JJ ------>authors6_c= ------>authors=Chen YW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=5 |