| Hsing CH |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=3.154 ------>paper_class3=2 ------>paper_class2=1 ------>vol=22 ------>confirm_bywho=shiemin ------>insert_bywho=hsing ------>Jurnal_Rank=20.0 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=20 ------>paper_class2Letter=None ------>page2=2238 ------>medlineContent= ------>unit=E0121 ------>insert_date=20080424 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Nephrology Dialysis Transplantation ------>paper_name=Expression of IL-19 correlates with Th2 cytokines in uraemic patients. ------>confirm_date=20080502 ------>tch_id=096035 ------>pmid=17449492 ------>page1=2230 ------>fullAbstract=BACKGROUND: Patients with end-stage renal disease are thought to be in a chronic state of inflammation. They also have an impaired immune response with a dysregulated Th1/Th2 cytokine network. Interleukin (IL)-19, which belongs to the IL-10 family, is a newly discovered proinflammatory cytokine. IL-19 alters the balance of Th1/Th2 cells in favour of Th2. The aims of the present study were to assess the changes in serum levels of IL-19 and their correlation with Th2 cytokine production in uraemic patients. METHODS: Seventy-three uraemic patients with haemodialysis were evaluated; 33 healthy volunteers served as controls. Serum levels of IL-19, -4, -5, -6, -10, -13 and tumour necrosis factor (TNF)-alpha were analysed using ELISA. Monocytes and T cells isolated from the patients and healthy volunteers were cultured in vitro, and cytokine production was determined. RESULTS: IL-19 expression in the patients; but not in healthy controls, correlated positively with both the proinflammatory cytokines (IL-6 and TNF-alpha) and the Th2 cytokines (IL-4, IL-5, IL-6, IL-10 and IL-13). Cultured monocytes from patients with high IL-19 serum levels produced more IL-19 in vitro. Additionally, uraemic serum or oxidized low-density lipoproteins up-regulated the IL-19 transcripts expression in resting monocytes. Compared with T cells from healthy controls, uraemic T cells expressed more endogenous Th2 cytokine transcripts and further responded to IL-19 stimulation in Th2 cytokine production in vitro. CONCLUSIONS: IL-19 expression in uraemic patients correlated with Th2 immune responses which might be involved in the cytokine dysregulation in uraemia. ------>tmu_sno=None ------>sno=18217 ------>authors2=Hsu CC ------>authors3=Chen WY ------>authors4=Chang LY ------>authors5=Hwang JC ------>authors6=Chang MS ------>authors6_c=??? ------>authors=Hsing CH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Expression of IL-19 correlates with Th2 cytokines in uraemic patients. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=4 |