| Chen CM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.875 ------>paper_class3=2 ------>paper_class2=1 ------>vol=62 ------>confirm_bywho=cmshih ------>insert_bywho=wanglf ------>Jurnal_Rank=8.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=558 ------>medlineContent= ------>unit=E0103 ------>insert_date=20080428 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=0031-3998 ------>authors_c= ------>score=500 ------>journal_name=Pediatr Res ------>paper_name=Retinoic acid fails to reverse oligohydramnios-induced pulmonary hypoplasia in fetal rats ------>confirm_date=20080502 ------>tch_id=062001 ------>pmid=18049370 ------>page1=553 ------>fullAbstract=All-trans retinoic acid (ATRA) stimulates platelet-derived growth factor (PDGF)-A expression and enhances alveolarization in rat lungs. On d 16 of gestation, pregnant Sprague-Dawley rats were randomly assigned to either a retinoic acid group (intragastric ATRA at 10 mg/kg body weight) or a vehicle group. We punctured each amniotic sac, and fetuses in the opposite uterine horn served as controls. On d 21 of gestation, the fetuses were delivered by cesarean section. Rats subjected to oligohydramnios exhibited significantly lower lung weights and lung/body weight ratios, and ATRA had no effects on the body or lung weights of oligohydramnios-exposed rats. Lung PDGF-A and -B mRNA expression was significantly lower in oligohydramnios-exposed rats compared with control littermates of maternal vehicle-treated dams. Maternal retinoic acid treatment significantly increased PDGF-A and -B mRNA expression in control and oligohydramnios-exposed rats compared with all rats and oligohydramnios-exposed rats of maternal vehicle-treated dams, respectively. Rats exposed to oligohydramnios exhibited a significantly lower generation of alveolar saccules than did control rats in the maternal retinoic acid- and vehicle-treated groups. In this model, maternal retinoic acid treatment showed no positive effects on oligohydramnios-induced pulmonary hypoplasia in the pseudoglandular stage. ------>tmu_sno=None ------>sno=18280 ------>authors2=Chou HC, Wa ------>authors3=Wang LF ------>authors4=Lang YD ------>authors5=Yeh CY ------>authors6= ------>authors6_c= ------>authors=Chen CM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Retinoic acid fails to reverse oligohydramnios-induced pulmonary hypoplasia in fetal rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=11 |