| Lee SL |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.286 ------>paper_class3=2 ------>paper_class2=1 ------>vol=13 ------>confirm_bywho=None ------>insert_bywho=wjhuang ------>Jurnal_Rank=29.4 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=6181 ------>medlineContent= ------>unit=000 ------>insert_date=20080505 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Bioorg. Med. Chem ------>paper_name=, Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs ------>confirm_date=None ------>tch_id=096017 ------>pmid=16084726 ------>page1=6175 ------>fullAbstract=Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 microM. ------>tmu_sno=None ------>sno=18367 ------>authors2=Huang WJ ------>authors3=Lin WW ------>authors4=Lee SS ------>authors5=Chen CH ------>authors6= ------>authors6_c= ------>authors=Lee SL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=1 |