| Mahindro N |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=4.926 ------>paper_class3=2 ------>paper_class2=1 ------>vol=49 ------>confirm_bywho=None ------>insert_bywho=wjhuang ------>Jurnal_Rank=8.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1216 ------>medlineContent= ------>unit=000 ------>insert_date=20080505 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J. Med. Chem ------>paper_name=Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies ------>confirm_date=None ------>tch_id=096017 ------>pmid=16451087 ------>page1=1212 ------>fullAbstract=A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPARgamma protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPARgamma protein resulting in potent activity. ------>tmu_sno=None ------>sno=18370 ------>authors2=Wang CC ------>authors3=Liao CC ------>authors4=Huang CF ------>authors5=Lu IL ------>authors6=Lien TW, Peng YH, Huang WJ, Lin YT ------>authors6_c= ------>authors=Mahindro N ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |