Lin CL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.628 ------>paper_class3=2 ------>paper_class2=1 ------>vol=73 ------>confirm_bywho=hsu0320 ------>insert_bywho=wjhuang ------>Jurnal_Rank=29.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1587 ------>medlineContent= ------>unit=G0200 ------>insert_date=20080505 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Planta Medica ------>paper_name=Novel ent-beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina ------>confirm_date=20080508 ------>tch_id=096017 ------>pmid=18080234 ------>page1=1581 ------>fullAbstract=Biotransformations of ENT-16beta-hydroxybeyeran-19-oic acid ( 1) by Mortierella isabellina produced hydroxylated metabolites. The isolated metabolites included three new compounds, ent-14beta,16beta-dihydroxybeyeran-19-oic acid ( 3), ent-12beta-hydroxy-16-oxobeyeran-19-oic acid ( 4), and ent-7alpha,12beta-dihydroxy-16-oxobeyeran-19-oic acid ( 5), and one known compound, ent-7alpha,16beta-dihydroxybeyeran-19-oic acid ( 2). The structural elucidation was achieved by detailed analysis of LC-MS chromatograms, and MS and NMR spectroscopic data. In this study, M. isabellina hydroxylated the basic skeleton beyeran-19-oic acid at the 7beta-, 12alpha-, and 14alpha-positions, and oxidized the skeleton at the 16-position. All compounds were evaluated with the cell viability assay. The results of the bioassay indicated that MTT formazan exocytosis occurs upon treatment of the cells with 1. ------>tmu_sno=None ------>sno=18379 ------>authors2=Lin SJ ------>authors3=Huang WJ ------>authors4=Ku YL ------>authors5=Tsai TH ------>authors6=Hsu FL ------>authors6_c= ------>authors=Lin CL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Novel ent-Beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=15 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |