| Peng SC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.206 ------>paper_class3=2 ------>paper_class2=1 ------>vol=105 ------>confirm_bywho=curator ------>insert_bywho=curator ------>Jurnal_Rank=35.7 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=479 ------>medlineContent= ------>unit=E0104 ------>insert_date=20080505 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1364-5072 ------>authors_c= ------>score=500 ------>journal_name=Journal of Applied Microbiology ------>paper_name=The antimicrobial activity of heyneanol A extracted from the root of taiwanese wild grape ------>confirm_date=20080926 ------>tch_id=074002 ------>pmid=18312569 ------>page1=485 ------>fullAbstract=AIMS: To search for antimicrobial compounds against pathogenic bacteria from grape vines (Vitis spp.). To investigate the antimicrobial efficacy of active compounds towards methicillin-resistant Staphylococcus aureus (MRSA). METHODS AND RESULTS: The root extracts of taiwanese wild grape (Vitis thunbergii var. taiwaniana) showed marked activities against Gram-positive bacteria using the disc diffusion method. After purification, the active compound 1 was confirmed as heyneanol A by mass spectroscopy and nuclear magnetic resonance. Heyneanol A showed an minimum inhibitory concentration (MIC) value of 2 microg ml(-1) towards MRSA and a value of 2 to 4 microg ml(-1) for Enterococcus faecium, S. aureus, Streptococcus agalactiae and Streptococcus pyogenes. In addition, the contents of heyneanol A were determined as 36 mg g(-1) in roots of taiwanese wild grape. CONCLUSIONS: The root extracts of grapevines have good antimicrobial activities towards some strains of Gram-positive pathogens. Heyneanol A, the major antimicrobial compound, is especially active towards MRSA. In addition, the abundances of heyneanol A and other stilbenes in the roots of grapevines make it possible to produce natural antimicrobial compounds from this plant species. SIGNIFICANCE AND IMPACT OF THE STUDY: This study reports for the first time the antimicrobial compounds in the root extracts of grapevines. The results will have clinical significance owing to their activities against MRSA. ------>tmu_sno=None ------>sno=18429 ------>authors2=Cheng CY ------>authors3=Sheu F ------>authors4=Su CH ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Peng SC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The antimicrobial activity of heyneanol A extracted from the root of Taiwanese wild grape. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |