| Chen CS |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.685 ------>paper_class3=2 ------>paper_class2=1 ------>vol=18 ------>confirm_bywho=hj2166 ------>insert_bywho=chwu ------>Jurnal_Rank=19.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=157 ------>medlineContent= ------>unit=E0110 ------>insert_date=20080507 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Toxicology ------>paper_name=NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis ------>confirm_date=20081003 ------>tch_id=071004 ------>pmid=18295389 ------>page1=148 ------>fullAbstract=The increased expression and cross-linking activity of tissue transglutaminase (tTG) have been demonstrated in acute liver injury and fibrosis. We focused on the molecular mechanisms that contribute to ethanol-induced tTG expression and investigated the efficacy of propolis components in preventing both the tTG expression in vitro and fibrogenesis in vivo. We demonstrate herein that both ERK1/2 and PI3K/Akt pathways can regulate the effects of ethanol on NF-kappaB-dependent transcription and these signaling pathways may be involved in activation of ethanol-mediated tTG expression. We also found that administration of pinocembrin (PIN), one of the major components of propolis, inhibited tTG activation and significantly prevented the development of thioacetamide (TAA)-induced liver cirrhosis. The present study suggests that tTG may be an important member of the cascade of factors necessary for ethanol-induced liver fibrogenesis and PIN could serve as an anti-fibrogenic agent. ------>tmu_sno=None ------>sno=18484 ------>authors2=Wu CH ------>authors3=Lai YC ------>authors4=Lee WS ------>authors5=Chen HM ------>authors6=Chen RJ, Chen LC, Ho YS, Wang YJ ------>authors6_c= ------>authors=Chen CS ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=4 |