| Hus CP |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.229 ------>paper_class3=2 ------>paper_class2=1 ------>vol=84 ------>confirm_bywho=ncchang ------>insert_bywho=cyhuang ------>Jurnal_Rank=18.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1287 ------>medlineContent= ------>unit=E0109 ------>insert_date=20080513 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Ann Thorac Surg ------>paper_name=Down Regulation of Apoptosis after Left Ventricular Aneurysm Repair ------>confirm_date=20080515 ------>tch_id=095003 ------>pmid=17888983 ------>page1=1289 ------>fullAbstract=BACKGROUND: Apoptosis is a common feature of the cardiomyopathic process contributing to progressive decline in ventricular function after transmural myocardial infarction. We hypothesized that left ventricular aneurysm repair (LVAR) down-regulates apoptotic potential of cardiomyocytes in the surviving myocardium. METHODS: In the rat infarct model, LV aneurysms were repaired by pursestring suture 2 weeks after coronary artery ligation. Cardiac function and myocardial infarction size were assessed by echocardiography and transverse heart sections, respectively, before sacrifice 12 weeks later. Cardiomyocytes and TdT-mediated dUTP terminal nick-end labeling (TUNEL) assays of apoptotic nuclei were analyzed adjacent to and remote from the aneurysm (8 in infarction group, 7 in aneurysm group, and 11 in repair group). Biochemical samples for immunoblot were also obtained from surviving myocardium. RESULTS: A statistically significant increase in apoptotic rate was seen in both adjacent and remote areas (p < 0.01) after aneurysm formation. After LVAR, heart function was improved, and TUNEL assays also show significant decrease when compared with aneurysm group. But significant decreases were noted only in activated caspase-9 and increases in Bcl-2 in immunoblot analysis when comparing repair group with aneurysm group. CONCLUSIONS: Down-regulation of apoptosis accounts for the change in the long-term benefit after LVAR. To prevent heart failure, LVAR is indicated when it is large enough, and the infarction area should be excluded as much as possible. ------>tmu_sno=None ------>sno=18635 ------>authors2=Huang CY ------>authors3=Shih CC ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Hus CP ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Down-regulation of apoptosis after left ventricular aneurysm repair. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=8 |