| Chi-Jung Chung |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=3.846 ------>paper_class3=2 ------>paper_class2=1 ------>vol=232 ------>confirm_bywho=ymhsueh ------>insert_bywho=ctsu ------>Jurnal_Rank=8.2 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=209 ------>medlineContent= ------>unit=J0200 ------>insert_date=20080716 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Toxicology and Applied Pharmacology ------>paper_name=Polymorphisms in Cell Cycle Regulatory Genes, Urinary Arsenic Profile and Urothelial Carcinoma ------>confirm_date=20091028 ------>tch_id=079012 ------>pmid=18640142 ------>page1=203 ------>fullAbstract=INTRODUCTION: Polymorphisms in p53, p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer risk. The goal of our study was to evaluate the roles of cell cycle regulatory gene polymorphisms in the carcinogenesis of arsenic-related urothelial carcinoma (UC). METHODS: A hospital-based case-controlled study was conducted to explore the relationships among the urinary arsenic profile, 8-hydroxydeoxyguanosine (8-OHdG) levels, p53 codon 72, p21 codon 31 and CCND1 G870A polymorphisms and UC risk. The urinary arsenic profile was determined using high-performance liquid chromatography (HPLC) and hydride generator-atomic absorption spectrometry (HG-AAS). 8-OHdG levels were measured by high-sensitivity enzyme-linked immunosorbent assay (ELISA) kits. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymerase (PCR-RFLP). RESULTS: Subjects carrying the p21 Arg/Arg genotype had an increased UC risk (age and gender adjusted OR=1.53; 95% CI, 1.02-2.29). However, there was no association of p53 or CCND1 polymorphisms with UC risk. Significant effects were observed in terms of a combination of the three gene polymorphisms and a cumulative exposure of cigarette smoking, along with the urinary arsenic profile on the UC risk. The higher total arsenic concentration, monomethylarsonic acid percentage (MMA%) and lower dimethylarsinic acid percentage (DMA%), possessed greater gene variant numbers, had a higher UC risk and revealed significant dose-response relationships. However, effects of urinary 8-OHdG levels combined with three gene polymorphisms did not seem to be important for UC risk. CONCLUSIONS: The results showed that the variant genotype of p21 might be a predictor of inorganic arsenic-related UC risk. ------>tmu_sno=None ------>sno=18735 ------>authors2=Chi-Jung Huang ------>authors3=Yeong-Shiau Pu ------>authors4=Chien-Tien Su ------>authors5=Yung-Kai Huang ------>authors6=Ying-Ting Chen,Yu-Mei Hsueh ------>authors6_c=??????? ------>authors=Chi-Jung Chung ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=7 |