Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chou HH, Takashiba S, Takigawa M, Nishimura F, Arai. H and Murayama Y.
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------>journal_name=Journal of Dental Research
------>paper_name=Roles of type II Interleukin-1 receptor expressed on human gingival fibroblasts.
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------>fullAbstract=The classic stimulus for cellular cytokine production is bacterial lipopolysaccharide (endotoxin). It was therefore hypothesized that tumor necrosis factor-alpha (TNF-alpha) may be responsible for pericoronitis. TNF-alpha and its receptors were detected by immunohistochemical staining in third molar pericoronitis in ten patients and ten healthy control samples. The percentage of TNF-alpha positive cells was high in pericoronitis (p = 0.0317). TNF receptors TNF-R1 and TNF-R2 were found in macrophage- and fibroblast-like cells, vascular endothelial cells in post-capillary venules, and basal epithelial cells in pericoronitis, but were only weakly expressed in controls. Increased expression of interleukin-1beta and vascular cell adhesion molecule-1 was found as a biological indicator of TNF-alpha ligand-receptor interaction. Explanted tissues acquired destructive potential upon TNF-alpha stimulation, whereas TNF-alpha blockers controlled it in inflamed tissues. These findings suggest that, in pericoronitis, inflammatory and resident cells produce and respond to potent pro-inflammatory cytokine TNF-alpha, with pathogenic and potential therapeutic relevance.
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------>authors=Chou HH, Takashiba S, Takigawa M, Nishimura F, Arai. H and Murayama Y.
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------>updateTitle=Role of TNF-alpha and its receptors in pericoronitis.
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------>publish_year=1997
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z