| Hsu KW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=6.420 ------>paper_class3=2 ------>paper_class2=1 ------>vol=28 ------>confirm_bywho=sihuang ------>insert_bywho=hsiehrh ------>Jurnal_Rank=12.9 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=4842 ------>medlineContent= ------>unit=J0500 ------>insert_date=20081003 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Mol Cell Biol ------>paper_name=The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity ------>confirm_date=20081003 ------>tch_id=088011 ------>pmid=18490439 ------>page1=4829 ------>fullAbstract=The Notch signal pathway plays multifaceted roles to promote or suppress tumorigenesis. The Notch1 receptor intracellular domain (N1IC), the activated form of the Notch1 receptor, activates the c-myc proto-oncogene. The complex of N1IC and transcription factor YY1 binds to the human c-myc promoter to enhance c-myc expression in a CBF1-independent manner. Here we demonstrated that N1IC interacted with the c-Myc-regulating proteins alpha-enolase and c-myc promoter binding protein 1 (MBP-1). Both alpha-enolase and MBP-1 suppressed the N1IC-enhanced activity of the c-myc promoter in a CBF1-independent manner. The YY1 response element in front of the P2 c-myc promoter was essential and sufficient for the modulation of c-myc by N1IC and alpha-enolase or MBP-1. Furthermore, N1IC, YY1, and alpha-enolase or MBP-1 but not CBF1 bound to the c-myc promoter through associating with the YY1 response element. Hemin-induced erythroid differentiation was suppressed by N1IC in K562 cells. This suppression was relieved by the expression of alpha-enolase and MBP-1. In addition, both alpha-enolase and MBP-1 suppressed the N1IC-enhanced colony-forming ability through c-myc. These results indicate that the activated Notch1 receptor and alpha-enolase or MBP-1 cooperate in controlling c-myc expression through binding the YY1 response element of the c-myc promoter to regulate tumorigenesis. ------>tmu_sno=None ------>sno=18848 ------>authors2=Hsieh RH ------>authors3=Lee YH ------>authors4=Chao CH ------>authors5=Wu KJ ------>authors6=Tseng MJ, Yeh TS ------>authors6_c= ------>authors=Hsu KW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=8 |