Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Jian JW
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------>vol=131
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------>Jurnal_Rank=52.0
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------>unit=E0310
------>insert_date=20081007
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------>journal_name=Virus Res.
------>paper_name=Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the 2004-2005 and 2006-2007 epidemics.
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------>pmid=17996973
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------>fullAbstract=Influenza B viruses were predominant in Taiwan during the 2004-2005 epidemic and both Victoria and Yamagata lineage viruses co-circulated. A reassortant influenza B virus that contained a Victoria lineage hemagglutinin (HA) gene and Yamagata lineage neuraminidase (NA) gene appeared first in 2002 and became predominant during the 2004-2005 epidemic. During the 2006-2007 epidemic, an influenza B outbreak occurred in Taiwan and only Victoria lineage viruses circulated. We characterized the viruses isolated in the 2006-2007 epidemic and found that the HA genes of influenza B viruses from that epidemic were highly similar to those from the 2004-2005 epidemic. We also analyzed the NA genes of isolates from the 2006-2007 epidemic and found that they all belonged to the Yamagata lineage and formed a new genetic subclade. Comparison of isolates from the 2004-2005 and 2006-2007 epidemics revealed four substitutions, N220K, E320D, K343R and E404K in NA genes. Although the HA sequences from the 2006-2007 epidemic were similar to those from the 2004-2005 epidemic, the NA sequences differed, suggesting distinct patterns of evolution of the HA and NA genes from 2004-2007 in Taiwan. This study emphasizes that the evolution of the NA genes may contribute to reemergence of influenza B viruses.
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------>authors2=Lai CT
------>authors3=Kuo CY
------>authors4=Kuo SH
------>authors5=Hsu LC
------>authors6=Chen PJ, Wu HS*, Liu MT*
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------>authors=Jian JW
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------>updateTitle=Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the 2004-2005 and 2006-2007 epidemics.
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------>no=2
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------>publish_year=2007
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------>publish_month=2
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z