Jian JW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.708 ------>paper_class3=2 ------>paper_class2=1 ------>vol=46 ------>confirm_bywho=leehorng ------>insert_bywho=wuhs ------>Jurnal_Rank=21.3 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1434 ------>medlineContent= ------>unit=E0310 ------>insert_date=20081007 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J Clin Microbiol ------>paper_name=Genetic and Epidemiological Analysis of Influenza Virus Epidemics in Taiwan during 2003 to 2006. ------>confirm_date=20081008 ------>tch_id=093109 ------>pmid=18256223 ------>page1=1426 ------>fullAbstract=The genetic characterization of Taiwanese influenza A and B viruses on the basis of analyses of pairwise amino acid variations, genetic clustering, and phylogenetics was performed. A total of 548, 2,123, and 1,336 sequences of the HA1 genes of influenza A virus subtypes H1 and H3 and influenza B virus, respectively, collected during 2003 to 2006 from an island-wide surveillance network were determined. Influenza A virus H3 showed activity during all periods, although it was dominant only in the winters of 2002-2003 and 2003-2004. Instead, influenza B virus and influenza A virus H1 were dominant in the winters of 2004-2005 and 2005-2006, respectively. Additionally, two influenza A virus H3 peaks were found in the summers of 2004 and 2005. From clustering analysis, similar characteristics of high sequence diversity and short life spans for the influenza A virus H1 and H3 clusters were observed, despite their distinct seasonal patterns. In contrast, clusters with longer life spans and fewer but larger clusters were found among the influenza B viruses. We also noticed that more amino acid changes at antigenic sites, especially at sites B and D in the H3 viruses, were found in 2003 and 2004 than in the following 2 years. The only epidemic of the H1 viruses, which occurred in the winter of 2005-2006, was caused by two genetically distinct lineages, and neither of them showed apparent antigenic changes compared with the antigens of the vaccine strain. For the influenza B viruses, the multiple dominant lineages of Yamagata-like strains with large genetic variations observed reflected the evolutionary pressure caused by the Yamagata-like vaccine strain. On the other hand, only one dominant lineage of Victoria-like strains circulated from 2004 to 2006. ------>tmu_sno=None ------>sno=18868 ------>authors2=Chen GW ------>authors3=Lai CT ------>authors4=Hsu LC ------>authors5=Chen PJ ------>authors6=Kuo HS, Wu HS*, Shih SR* ------>authors6_c= ------>authors=Jian JW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Genetic and epidemiological analysis of influenza virus epidemics in Taiwan during 2003 to 2006. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=4 |