Wang YH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=0.769 ------>paper_class3=2 ------>paper_class2=1 ------>vol=15 ------>confirm_bywho=hychiou ------>insert_bywho=hychiou ------>Jurnal_Rank=85.5 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1034 ------>medlineContent= ------>unit=J0200 ------>insert_date=20081008 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=International Journal of Urology ------>paper_name=Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population ------>confirm_date=20090319 ------>tch_id=079002 ------>pmid=19120511 ------>page1=1029 ------>fullAbstract=OBJECTIVES: To investigate the association between genetic polymorphism of sulfotransferase1A1 (SULT1A1), cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population. METHODS: In a hospital-based case-control study, a total of 300 urothelial cancer (UC) cases and 300 cancer-free controls frequency-matched by age and gender were recruited from September 1998 to December 2005. The SULT1A1 arginine213histidine (Arg213His) polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: We found that the significantly increased UC risks of ever smokers and heavy smokers (> or =28 pack-years) were 2.1 (95% confidence interval [CI] = 1.4-3.3) and 2.2 (95% CI = 1.3-3.6), respectively. An increased UC risk of 1.8 (95% CI = 0.8-3.8) was observed among individuals with more than one item of hazardous chemical exposure, but it was not statistically significant. Compared with study subjects carrying the SULT1A1 Arg/Arg genotype, those with SULT1A1 Arg/His or His/His genotypes have a significantly decreased UC risk (Odds ratio [OR] = 0.5, 95% CI = 0.3-0.8). Heavy smokers carrying the SULT1A1 Arg/Arg genotype have a significantly increased UC risk (OR = 5.2, 95% CI = 2.3-11.6). Individuals who had been exposed to more than one item of hazardous chemicals and who carried the SULT1A1 Arg/Arg genotype have a significantly increased UC risk (OR = 3.7, 95% CI = 1.4-9.7). The highest significant increased UC risk (OR = 16.1, 95% CI = 2.9-87.2) was observed among ever smokers with hazardous chemical exposure and the SULT1A1 Arg/Arg genotype. CONCLUSIONS: SULT1A1 Arg213His polymorphism is associated with the development of UC, especially among cigarette smokers exposed to hazardous chemicals. ------>tmu_sno=None ------>sno=18871 ------>authors2=Juang GD ------>authors3=Hwang Thoma IS ------>authors4=Shen CH ------>authors5=Shao KY ------>authors6=Chiou HY ------>authors6_c= ------>authors=Wang YH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=12 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=12 |