Wu TH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.802 ------>paper_class3=2 ------>paper_class2=1 ------>vol=x ------>confirm_bywho=amel ------>insert_bywho=thwu ------>Jurnal_Rank=27.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=5 ------>paper_class2Letter=None ------>page2=press ------>medlineContent= ------>unit=G0100 ------>insert_date=20081027 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Prog Neuropsychopharmacol Biol Psychiatry. ------>paper_name=Pharmacokinetics of olanzapine in Chinese male schizophrenic patients with various smoking behaviors. ------>confirm_date=20081127 ------>tch_id=091080 ------>pmid=18796323 ------>page1=in ------>fullAbstract=Tobacco consumption has been recognized as a factor mediating the interindividual variations in olanzapine~s pharmacokinetics and pharmacodynamics. The primary objective of this study was to describe the dose effect of smoking on the dose-plasma concentration relationship and the pharmacokinetics of oral olanzapine in male schizophrenic patients using high-performance liquid chromatography coupled with electrochemical detector. Twenty-seven male schizophrenic inpatients were recruited and were stratified into the following groups according to smoking behaviors: non-smokers (n=9), light-smokers (1-4 cigarettes per day; n=9), and heavy-smokers (>or=5 cigarettes per day; n=9). Plasma olanzapine concentrations were determined up to 120 h following a single oral dose of 10 mg olanzapine. The pharmacokinetic parameters were calculated by the non-compartment method using WinNonlin software. Results show that there was a significant correlation among non-smokers (n=9; 0.79; p=0.01) or combined with light-smokers (n=18; 0.62; p<0.01) between peak plasma olanzapine concentrations (Cmax) and their individual dose-corrected by body weight, but this correlation did not appear in heavy-smokers. There were no significant differences between non-smokers and light-smokers except for significant decreased AUC0-->120 by 45.1% in light-smokers. The mean C(max) and the mean area under the plasma concentration-time curve from time zero to 120 h (AUC0-->120) of the heavy-smoking patients was 9.3+/-4.3 ng/ml (65.2% reduction compared to the non-smokers) and 302.4+/-167.8 h ng/ml (67.6% reduction compared to the non-smokers), respectively. In summary, a daily consumption of 5 cigarettes is probably sufficient for induction of olanzapine metabolism. Smoking cessation is recommended for olanzapine therapy to have better prediction for therapeutic dosages particularly in heavy-smokers. Compared to non-smokers, heavy-smokers therefore require a 50-100% increase in olanzapine doses. Therapeutic drug monitoring will need to be considered when schizophrenic patients change their smoking behaviors. ------>tmu_sno=None ------>sno=18929 ------>authors2=Chiu CC ------>authors3=Shen WW ------>authors4=Lin FW ------>authors5=Wang LH ------>authors6=Chen HY, Lu ML ------>authors6_c= ------>authors=Wu TH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Pharmacokinetics of olanzapine in Chinese male schizophrenic patients with various smoking behaviors. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=9 |