| Liou JP |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=4.895 ------>paper_class3=2 ------>paper_class2=1 ------>vol=51 ------>confirm_bywho=amel ------>insert_bywho=jpl ------>Jurnal_Rank=9.8 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=28 ------>paper_class2Letter=None ------>page2=4355 ------>medlineContent= ------>unit=G0100 ------>insert_date=20081118 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Journal of Medicinal Chemistry ------>paper_name=Discovery of 4-Amino and 4-Hydroxy-1-Aroylindoles as Potent Tubulin Polymerization Inhibitors ------>confirm_date=20081119 ------>tch_id=093131 ------>pmid=18588280 ------>page1=4351 ------>fullAbstract=1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 50 of 0.9 and 0.6 microM, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC 50 of 0.3-5.4 nM in a set of human cancer cell lines. ------>tmu_sno=None ------>sno=19143 ------>authors2=Wu ZY ------>authors3=Kuo CC ------>authors4=Chang CY ------>authors5=Lu PY ------>authors6=Chen CM, Hsieh HP, Chang JY ------>authors6_c=???, ???, ??? ------>authors=Liou JP ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=6 |