Reddy GR |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=4.898 ------>paper_class3=2 ------>paper_class2=1 ------>vol=51 ------>confirm_bywho=amel ------>insert_bywho=jpl ------>Jurnal_Rank=7.5 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=20 ------>paper_class2Letter=None ------>page2=8167 ------>medlineContent= ------>unit=G0100 ------>insert_date=20081118 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=447 ------>journal_name=Journal of Medicinal Chemistry ------>paper_name=Synthesis and Structure-Activity Relationships of 2-Amino and 2-Hydroxy-1-Aroylnaphthalenes as Potent Antitubulin Agents ------>confirm_date=20090925 ------>tch_id=093131 ------>pmid=19053773 ------>page1=8163 ------>fullAbstract=A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative activity with IC(50) values of 2.1-26.3 nM against a panel of human cancer cell lines including multiple-drug resistant cell line. Compound 9 demonstrated better antiproliferative activity and has a comparable tubulin binding efficacy as that of colchicine. ------>tmu_sno=None ------>sno=19156 ------>authors2=Kuo CC ------>authors3=Tan UK ------>authors4=Coumar MS ------>authors5=Chang CY ------>authors6=Lai MJ, Wu SY, Chang JY, Liou JP, Hsieh HP ------>authors6_c= ------>authors=Reddy GR ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=12 |