Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Reddy GR
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------>insert_date=20081118
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------>journal_name=Journal of Medicinal Chemistry
------>paper_name=Synthesis and Structure-Activity Relationships of 2-Amino and 2-Hydroxy-1-Aroylnaphthalenes as Potent Antitubulin Agents
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------>fullAbstract=A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative activity with IC(50) values of 2.1-26.3 nM against a panel of human cancer cell lines including multiple-drug resistant cell line. Compound 9 demonstrated better antiproliferative activity and has a comparable tubulin binding efficacy as that of colchicine.
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------>authors2=Kuo CC
------>authors3=Tan UK
------>authors4=Coumar MS
------>authors5=Chang CY
------>authors6=Lai MJ, Wu SY, Chang JY, Liou JP, Hsieh HP
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------>authors=Reddy GR
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------>updateTitle=Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
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------>publish_year=2008
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------>publish_month=12
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z