| Ching-Yin Ho |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.363 ------>paper_class3=2 ------>paper_class2=1 ------>vol=22 ------>confirm_bywho=weinan ------>insert_bywho=hunghuey ------>Jurnal_Rank=33.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=467 ------>medlineContent= ------>unit=F0300 ------>insert_date=20081118 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=American Journal of Rhinology ------>paper_name=Ozone-induced nasal hyperresponsiveness to tachykinins in guinea pigs ------>confirm_date=20090325 ------>tch_id=093038 ------>pmid=18954503 ------>page1=463 ------>fullAbstract=OBJECTIVE: To assess role of hydroxyl radials in the ozone-induced upper airway hyper-responsiveness to tachykinins. METHODS: A prospective, controlled, animal model (n = 96) was performed. Half of them exposed to air (A-group, placebo) and the other half exposed to 3 ppm ozone (O-group) for 2 h. Two hours post air/ozone exposure, animals were anesthetized and equally randomized to be pretreated with one of the three treatments, including saline vehicle, dimethylthiourea (DMTU; 500 mg/kg m, a hydroxyl radical scavenger), or phosphoramidon (Phos; 2 mg/kg, an inhibitor for neutral endopeptidase). Ten minutes after pretreatment, half of the animals in each group were i.v. injected with capsaicin (2 microg/kg), and the other half were i.v. injected with substance P (10 microg/kg) to produce Evans blue dye extravasation. RESULTS: Nasal exudative response to capsaicin or substance P in O-group was found to be significantly greater than that in A-group. This ozone-induced nasal airway hyperresponsiveness was largely prevented by DMTU. Phosphoramidon produced a similar nasal airway hyperresponsiveness in the A-group, but failed to alter ozone-induced nasal airway hyperresponsiveness in O-group. In sharp contrast, only substance P, but not capsaicin, produced a laryngeal exudative response in the A-group, which was similar to that in the O-group. The laryngeal exudative response to substance P was not significantly affected by DMTU or Phos. CONCULSION: In the guinea-pig model, hydroxyl radicals play a vital role in the development of ozone-induced nasal airway hyperresponsiveness to tachykinins. It is possibly mediated through the suppressive action of ozone on the tachykinin degradation. ------>tmu_sno=None ------>sno=19160 ------>authors2=Ching-Ting Tan ------>authors3=Hung-Huey Tsai ------>authors4=Y. R. Kou ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Ching-Yin Ho ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Ozone-induced nasal hyperresponsiveness to tachykinins in guinea pigs. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |