| Cheuk-Sing Choy |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.049 ------>paper_class3=2 ------>paper_class2=1 ------>vol=115 ------>confirm_bywho=sylin ------>insert_bywho=e5168 ------>Jurnal_Rank=24.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=462 ------>medlineContent= ------>unit=E0125 ------>insert_date=20081118 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Ethnopharmacology ------>paper_name=Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis Draconis, a dragon's blood resin, in RAW 264.7 cells ------>confirm_date=20081118 ------>tch_id=089053 ------>pmid=18060707 ------>page1=455 ------>fullAbstract=Sanguis Draconis (SD) is a kind of dragon~s blood resin that is obtained from Daemomorops draco (Palmae). It is used in traditional medicine and has shown anti-inflammatory activity in some diseases. In this study, we examined the effects of Sanguis Dranonis ethanol extract (SDEE) on LPS-induced inflammation using RAW 264.7 cells. Our data indicated that SDEE inhibits LPS-stimulated NO, PGE2, IL-1 beta and TNF-alpha release, and iNOS and COX-2 expression. Furthermore, SDEE suppressed the LPS-induced p65 expression of NF-kappa B, which was associated with the inhibition of I kappa B-alpha degradation. We also found that the expression of HO-1 was significantly increased in RAW 264.7 cells by SDEE. These results suggest among possibilities of anti-inflammation that SDEE inhibits the production of NO and PGE2 by the down-regulation of iNOS and COX-2 gene expression via the suppression of NF-kappaB (p65) activation. SDEE can induce HO-1 over-expression in macrophage cells, which indicates that it may possess antioxidant properties. This result means that SEDD its anti-inflammatory effects in macrophages may be through a novel mechanism that involves the action of HO-1. Thus, SD could provide a potential therapeutic approach for inflammation-associated disorders. ------>tmu_sno=None ------>sno=19195 ------>authors2=Chien-Ming Hu ------>authors3=Wen-Ta Chiu ------>authors4=Carlos-Shu Kei Lam ------>authors5=Yih Ting ------>authors6=Shin-Han Tsai, Tzu-Chien Wang* ------>authors6_c= ------>authors=Cheuk-Sing Choy ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis Draconis, a dragon~s blood resin, in RAW 264.7 cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |