| Lin HH |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=3.377 ------>paper_class3=2 ------>paper_class2=1 ------>vol=26 ------>confirm_bywho=hychiou ------>insert_bywho=liyu ------>Jurnal_Rank=1.5 ------>authors4_c=??? ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=5 ------>paper_class2Letter=None ------>page2=3420 ------>medlineContent= ------>unit=J0200 ------>insert_date=20081118 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=6 ------>ISSN= ------>authors_c=??? ------>score=492 ------>journal_name=Vaccine ------>paper_name=HLA and response to booster hetatitis B vaccine in anti-HBs-seronegative adolescents who had received primary infantile vaccination ------>confirm_date=20081211 ------>tch_id=097008 ------>pmid=18501999 ------>page1=3414 ------>fullAbstract=To explore contemporarily genetic and non-genetic determinants of long-term immunological memory to hepatitis B (HB) vaccination, we conducted a case-control study nested in an adolescent cohort of booster recipients who had received primary infantile HB vaccination but with residual anti-HBs titers <10 mIU/mL at 15-18 years of age. High-resolution phenotypes of human leukocyte antigen (HLA)-A, -B, and -DRB1 loci were determined by sequence-specific oligonucleotide probe hybridization. After controlling for pre-booster anti-HBs levels, the absences of HLA-A*02 and -DRB1*08, simply expressed as A*02(-) and -DRB1*08(-), and the presence of B*15 were significantly associated with elevated risks of non-response (post-booster anti-HBs titers<10 mIU/mL) to booster vaccination. The adjusted odds ratios (ORs) were 3.85 (CI, 1.82-8.33), 4.55 (CI, 1.23-16.67), 3.59 (CI, 1.40-9.17), respectively. There was multiplicative synergism between A*02 and B*15 on the risk of non-response to booster vaccination. The multivariate-adjusted ORs for A*02(-)/B*15, A*02(-)/B*15(-), A*02/B*15, and A*02/B*15(-) haplotypes were 20.39 (p=0.0003), 3.29 (p=0.007), 1.32 (p>0.05), and 1.0, respectively. Recent cigarette smoking and/or betel-quid chewing was associated with a 12-fold risk of non-response to booster vaccination. Further comparisons between responders and adolescents who had undetectable post-booster anti-HBs titers (<0.1 mIU/mL) demonstrated similar results. Our results indicated that response to booster HB vaccination as well as long-term immunological responses to HB vaccination are closely related with host genetic factors, and probably modified by recent substance use. ------>tmu_sno=None ------>sno=19199 ------>authors2=Chang Liao HW ------>authors3=Lin SK ------>authors4=Wang LY ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lin HH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=???? ------>publish_area=0 ------>updateTitle=HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=27 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=5 |