| Lee HL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.279 ------>paper_class3=2 ------>paper_class2=1 ------>vol=17 ------>confirm_bywho=hychiou ------>insert_bywho=ymhsueh ------>Jurnal_Rank=15.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=3395 ------>medlineContent= ------>unit=E0108 ------>insert_date=20081118 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=469 ------>journal_name=Cancer Epidemiology, Biomarkers & Prevention. ------>paper_name=Correlation Between the Urine Profile of 4-(Methylnitrosamino)- 1-(3-Pyridyl)-1-Butanone Metabolites and 7-Methylguanine in Urothelial Carcinoma Patients. ------>confirm_date=20081212 ------>tch_id=073001 ------>pmid=19064555 ------>page1=3390 ------>fullAbstract=A major carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is present in cigarette smoke and its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), is used as an exposure biomarker for environmental tobacco smoke (ETS). This metabolite (NNAL) can be either detoxified into glucuronidated NNAL (NNAL-Gluc) or activated into an unstable reactive metabolite that methylates DNA along with formation of 4-hydroxy-4-(3-pyridyl)-butyric acid [hydroxy acid (HA)]. Therefore, the carcinogenic risk associated with ETS exposure is greatly modulated by individual variations in metabolic activation and detoxification capabilities. In this study, we defined the urinary HA/total NNAL [HA/total NNAL] ratio as the activation index and NNAL-Gluc/free NNAL [(total NNAL-free NNAL)/free NNAL] ratio as the detoxification index of NNK. The major methylated DNA adduct N(7)-methylguanine (N(7)-MeG), considered as the carcinogenic biomarker for cigarette smoking, was excreted in urine. The objective of this study was to investigate the effects of these metabolic indexes of NNK on N(7)-MeG urinary excretion in a population of urothelial carcinoma patients. Urinary levels of total NNAL (free NNAL plus NNAL-Gluc), free NNAL, HA, and N(7)-MeG were positively correlated with smoking. Furthermore, activation index and detoxification index correlated positively and negatively with N(7)-MeG levels, respectively. Our results suggest that these metabolic indices may represent the phenotype of individual metabolism capability and modulate the carcinogenic risk of ETS exposure. ------>tmu_sno=None ------>sno=19224 ------>authors2=Hsueh YM ------>authors3=Chung CJ ------>authors4=Pu YS ------>authors5=Chang LW ------>authors6=Hsieh DPH,Liou SH, Lin P. ------>authors6_c= ------>authors=Lee HL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=12 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=12 |