Lin SJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.662 ------>paper_class3=2 ------>paper_class2=1 ------>vol=16 ------>confirm_bywho=amel ------>insert_bywho=lmyang ------>Jurnal_Rank=31.7 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=2706 ------>medlineContent= ------>unit=G0100 ------>insert_date=20081119 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=493 ------>journal_name=Bioorg. Med. Chem. ------>paper_name=Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonaimdes ------>confirm_date=20081121 ------>tch_id=078012 ------>pmid=18063374 ------>page1=2697 ------>fullAbstract=Two series of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamide derivatives were designed and synthesized for the evaluation as selective cyclooxygenase-2 (COX-2) inhibitors in a cellular assay using human whole blood (HWB). Extensive structure-activity relationships (SAR) were studied within these series. Several compounds were found to be novel and selective COX-2 inhibitors. Among them, the most potent and selective was 4-(3-carboxy-4-hydroxy-benzylideneamino)benzenesulfonamide (20, LA2135), (IC(50)~s for COX-1: 85.13 microM; COX-2: 0.74 microM; SI: 114.5), being more active COX-2 selective than celecoxib. ------>tmu_sno=None ------>sno=19319 ------>authors2=Tsai WJ ------>authors3=Chiou WF ------>authors4=Yang TH ------>authors5=Yang LM ------>authors6= ------>authors6_c= ------>authors=Lin SJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=2 |