| Tsai WJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.604 ------>paper_class3=2 ------>paper_class2=1 ------>vol=16 ------>confirm_bywho=amel ------>insert_bywho=lmyang ------>Jurnal_Rank=34.1 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=4443 ------>medlineContent= ------>unit=G0100 ------>insert_date=20081119 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=385 ------>journal_name=Bioorg. Med. Chem. Lett. ------>paper_name=Selective COX-2 inhibitors. Part I: Synthesis and biological evaluation of phenylazobenzenesulfonaimdes ------>confirm_date=20081121 ------>tch_id=078012 ------>pmid=16814546 ------>page1=4440 ------>fullAbstract=A series of phenylazobenzenesulfonamide derivatives were designed and synthesized for the evaluation as selective cyclooxygenase-2 (COX-2) inhibitors in a cellular assay using human whole blood (HWB) and an enzymatic assay using purified ovine enzymes. Extensive structure-activity relationships (SAR) were studied within this series, and several of selective COX-2 inhibitors have been identified. Among them, compound 8, 4-(4-amino-2-methylsulfanyl-phenylazo)benzenesulfonamide, showed a potent inhibitory activity to the cyclooxygenase enzymes (IC(50)~s for COX-1: 23.28 microM; COX-2: 2.04 microM), being active but less COX-2 selective than celecoxib. ------>tmu_sno=None ------>sno=19325 ------>authors2=Shiao YJ ------>authors3=Lin SJ ------>authors4=Chiou WF ------>authors5=Lin LC ------>authors6=Yang TH, Teng CM, Wu TS, Yang LM ------>authors6_c= ------>authors=Tsai WJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |