| Yang LM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.848 ------>paper_class3=2 ------>paper_class2=1 ------>vol=70 ------>confirm_bywho=amel ------>insert_bywho=lmyang ------>Jurnal_Rank=27.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=363 ------>medlineContent= ------>unit=G0100 ------>insert_date=20081119 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Planta Med. ------>paper_name=Hydroxylation and glucosidation of ent-16beta-hydroxybeyeran-19-oic acid by Bacillus megaterium and Aspergillus niger ------>confirm_date=20081121 ------>tch_id=078012 ------>pmid=15095153 ------>page1=359 ------>fullAbstract=ent-16beta-Hydroxybeyeran-19-oic acid ( 1) has potential antihypertensive activity. To obtain novel and more-effective compounds, 1 was incubated with Bacillus megaterium ATCC 14 581 and Aspergillus niger CCRC 32 720. The structures of the metabolites were determined by HR-FAB-MS, 1D- and 2D-NMR spectral data, and enzymatic hydrolysis. Bacillus megaterium hydroxylated and glucosidated 1 to yield ent-7alpha,16beta-dihydroxybeyeran-19-oic acid ( 2), ent-16beta-hydroxybeyeran-19-oic acid alpha- D-glucopyranosyl ester ( 3), and ent-7alpha,16beta-dihydroxybeyeran-19-oic acid alpha- D-glucopyranosyl ester ( 4). Aspergillus niger hydroxylated 1 to yield ent-1beta,7alpha,16beta-trihydroxybeyeran-19-oic acid ( 5) and ent-1beta,7alpha-dihydroxy-16-oxobeyeran-19-oic acid ( 6). Metabolites 3 - 5 were characterized as new compounds. In addition, 2, 3, 5, and 6 were tested for antihypertensive effects, and we found that 5 and 6 were more potent than the parent compound 1. ------>tmu_sno=None ------>sno=19327 ------>authors2=Hsu FL ------>authors3=Cheng JT ------>authors4=Chang CH ------>authors5=Liu PC ------>authors6=Lin SJ ------>authors6_c= ------>authors=Yang LM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Hydroxylation and glucosidation of ent-16beta-Hydroxybeyeran-19-oic acid by Bacillus megaterium and Aspergillus niger. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=1 |