Taipei Medical University

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Chiu, H. -D., Huang, H. -M., Lee, M. -C.
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------>journal_name=Annual Sympoium of the Biomechanical Engineering Society ROC
------>paper_name=Dynamic Analysis of the Human Head
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------>fullAbstract=Autoregulation capacity has been classically assessed with a ~two-point~ measurement or static autoregulation (sAR). In such an approach, stabilized hemodynamic parameters are determined before and after a perfusion pressure challenge. Analysis of dynamic autoregulation (dAR), an early phase of blood flow response to a sudden perfusion pressure change is emerging as a preferred approach to assess the capacity of autoregulation in many non-ocular tissues and has developed rapidly in the last decade. The purpose of this study was to develop a method to quantify dAR in the optic nerve head (ONH). In six pentobarbital (6-9 mg/kg/h, IV) anesthetized rhesus monkeys, dAR was elicited by increasing intraocular pressure (IOP) from 10 to 30 or 40 mmHg (IOP(10-30)/IOP(10-40)) manometrically via switch between reservoirs connected to the anterior chamber. Relative blood flow changes during dAR in the ONH, estimated with a laser speckle flowgraph (LSFG), were continuously measured for 1 min. Time-domain parameters of dAR response, including: BF(Deltamax) (maximal blood flow decrease, %), K(r) (descending slope of blood flow from baseline to BF(Deltamax)) and T(r) (descending time of blood flow from baseline to BF(Deltamax)) were extracted and analyzed offline. For each monkey, same procedure was repeated three times during three different visits. The test-retest repeatability and inter-ocular difference of the parameters was statistically evaluated. During IOP(10-30) and IOP(10-40), the mean arterial BP was 89 +/- 7 and 85 +/- 6 mmHg, respectively. Immediately after the reservoir was switched, the blood flow started to decline and reached maximal in approximately 4 s. The blood flow then returned back toward baseline despite continuous IOP increase, which took 8-11 s to reach the level of the raised reservoir. The general pattern of blood flow responses was similar between IOP(10-30) and IOP(10-40) and there was no statistically significant difference for T(r) (P > 0.05). However, IOP(10-40) caused greater BF(Deltamax) and deeper K(r) than IOP(10-30) (P < 0.0001 and P < 0.05, respectively). The blood flow during steady state, 5 min after IOP elevation, showed no statistically significant difference from baseline (P > 0.05). All dAR parameters (T(r), K(r) and BF(Deltamax)) showed no significant difference across the 3 visits (Repeat measures ANOVA, P = 0.7, 0.2 and 0.2, respectively); the corresponding coefficients of variance were 24%, 43% and 34% during IOP(10-30) and 11.8%, 30.3% and 19.0% during IOP(10-40). The mean dAR parameters between the eyes showed no statistically differences (P = 0.6) during both IOP(10-30) and IOP(10-40). The current study showed that a rapid ocular perfusion pressure decrease induced by a sudden IOP step increase evoked a transient and reproducible dAR response in the ONH of non-human primates measured with LSFG. Quantitative analysis of dAR may provide a direct view of vasomotorial activity in the resistant vessels and thus a new approach to assess the autoregulatory capacity in the ONH.
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------>authors=Chiu, H. -D., Huang, H. -M., Lee, M. -C.
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------>updateTitle=Quantification of dynamic blood flow autoregulation in optic nerve head of rhesus monkeys.
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------>publish_year=1992
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z