Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Kao SH
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------>journal_name=American Society for Reproductive Medicine 64th Annual Meeting , 2008 November 8-12, San Francisco, California. A-185
------>paper_name=Osteopontin in the endometriosis
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------>fullAbstract=PROBLEM: The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels in patients with endometriosis. METHOD OF STUDY: A total of 79 patients with histologically confirmed endometriosis and 43 patients without endometriosis participated in this study. OPN mRNA expression in endometrial tissues was measured by real-time quantitative polymerase chain reaction (PCR) and plasma concentrations of OPN were quantified using a specific commercial sandwich enzyme-linked immunosorbent assays (ELISA). RESULTS: Osteopontin mRNA expression in endometrial tissue was significantly higher in women with endometriosis than in controls (P = 0.010). The mean plasma levels of OPN (mean +/- S.E.M.) in patients with endometriosis and controls were 407.31 +/- 37.80 ng/mL and 165.84 +/- 19.29 ng/mL, respectively (P < 0.001). Receiver operating characteristic (ROC) analysis for plasma OPN revealed an area under the curve (AUC) of 0.894, with a sensitivity of 93.0%, specificity of 72.4%, positive likelihood ratio of 3.37, and negative likelihood ratio of 0.1 using a cut-off value of 167.68 ng/mL. CONCLUSION: Osteopontin may be involved in the pathogenesis of endometriosis and plasma OPN may be a useful non-invasive marker for the diagnosis of endometriosis.
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------>authors2=Lee YR
------>authors3=Tzeng CR
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------>authors=Kao SH
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------>updateTitle=Endometrial osteopontin mRNA expression and plasma osteopontin levels are increased in patients with endometriosis.
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------>publish_year=2008
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z