| Ko YP |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=1 ------>vol=45 ------>confirm_bywho=sheujr ------>insert_bywho=cjhuang ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=147 ------>medlineContent= ------>unit=E0106 ------>insert_date=20081121 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Acta Anaesthesiologica Taiwanica ------>paper_name=Simulation analysis of the performance of target-controlled infusion of propofol in Chinese patients ------>confirm_date=20081124 ------>tch_id=093110 ------>pmid=17972616 ------>page1=141 ------>fullAbstract=BACKGROUND: The performance of target-controlled infusion (TCI) devices is important for the safety of patients. This study examined the performance of two propofol pharmacokinetic parameter sets in Chinese patients by computer simulation. METHODS: Two sets of propofol pharmacokinetic parameters respectively derived from Marsh~s and Schnider~s studies were compared with those obtained in Chinese subjects from Li~s study. Pharmacokinetic parameters of propofol from Li~s study for subjects of three different entities (average adult, obese adult, and elderly) were used to estimate the performance of Marsh~s and Schnider~s models. Sixty virtual patients were generated with Li~s parameters. A computer program, STANPUMP, was used to perform the pharmacokinetic simulation. An induction dose of propofol at 2 mg/kg for average or obese adult, while 1.5 mg/kg for the elderly, followed by TCI of 4 microg/mL (average and obese adult) or 3 microg/mL (elderly) were simulated. The infusion schemes generated by STANPUMP using Marsh~s or Schnider~s model were put in to simulate the predicted plasma concentration based on the pharmacokinetic parameters from Li~s study. The median performance error (MDPE) and absolute median performance error (MDAPE) were calculated to estimate the bias and inaccuracy. Differences between models were calculated using the paired t test. A P value < 0.05 was considered statistically significant. RESULTS: The bias and inaccuracy by Marsh~s model in average adults were -11.9% and 18.5% respectively and by Schnider~s model were -8.6% and 17.9%. For obese adults, the bias and inaccuracy were 6.3% and 26.2% respectively for Marsh~s model and -6.6% and 22.6% for Schnider~s model. Sohnider~s model resulted in a significantly greater inaccuracy than Marsh~s model (42.1% versus 15.5%) when applied to elderly patients. CONCLUSIONS: The performance of TCI infusion of propofol in Chinese patients is generally acceptable with Marsh~s or Schnider~s model apart from using Schnider~s model in Chinese elderly patients. Further study to investigate the difference of propofol pharmacokinetics between Chinese and non-Chinese elderly patients is necessary. ------>tmu_sno=None ------>sno=19698 ------>authors2=Hsu YW ------>authors3=Hsu K ------>authors4=Tsai HJ ------>authors5=Huang CJ ------>authors6=Chen CC ------>authors6_c= ------>authors=Ko YP ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Simulation analysis of the performance of target-controlled infusion of propofol in Chinese patients. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=NULL ------>no=3 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=9 |