| Chang KY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.836 ------>paper_class3=2 ------>paper_class2=1 ------>vol=13 ------>confirm_bywho=sheujr ------>insert_bywho=cjhuang ------>Jurnal_Rank=30.9 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=153 ------>medlineContent= ------>unit=E0106 ------>insert_date=20081121 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Surgical Research ------>paper_name=HO-1 mediates the effects of HBO pretreatment against sepsis ------>confirm_date=20081124 ------>tch_id=093110 ------>pmid=16930622 ------>page1=143 ------>fullAbstract=BACKGROUND: We have recently shown that attenuation of sepsis-induced lung injury by hyperbaric oxygen (HBO) pretreatment involves expression regulation of inducible nitric oxide synthase (iNOS) and heme oxygenase (HO)-1. This study was performed to determine the effects of HBO pretreatment on acute kidney and liver injuries in septic rats and the roles of iNOS and HO-1. MATERIALS AND METHODS: One group of adult male rats (n = 48) were pretreated with HBO. The other group of rats (n = 48) breathed air at normal atmospheric pressure instead. Rats in each group were randomly allocated to receive injection of lipopolysaccharide (LPS), normal saline (N/S), LPS plus hemin (a HO-1 inducer), hemin, LPS plus SnPP (a HO-1 inhibitor), SnPP, LPS plus hemin plus SnPP, or hemin plus SnPP. Hemin and SnPP were injected at 1 h before HBO or air pretreatment. Rats were maintained for 6 h before sacrifice. RESULTS: LPS caused prominent kidney and liver injuries as well as iNOS and HO-1 expression in stimulated rats. HBO pretreatment significantly attenuated LPS-induced kidney but not liver injury. However, in conjunction with hemin (a HO-1 inducer), HBO pretreatment did attenuate LPS-induced liver injury. In addition, the inhibition of iNOS expression by HBO pretreatment was associated with "super-induction" (i.e., further enhancement) of LPS-induced HO-1 expression. Furthermore, the therapeutic effect of HBO could be counteracted by SnPP (a HO-1 inhibitor). CONCLUSIONS: HBO pretreatment significantly attenuates LPS-induced acute organ injuries in septic rats. The beneficial effect of HBO pretreatment against sepsis is mediated, at least in part, by "super-induction" of HO-1. ------>tmu_sno=None ------>sno=19699 ------>authors2=Tsai PS ------>authors3=Huang TY ------>authors4=Wang TY ------>authors5=Yang S ------>authors6=Huang CJ ------>authors6_c= ------>authors=Chang KY ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=HO-1 mediates the effects of HBO pretreatment against sepsis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=11 |