Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hsu MJ
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------>journal_name=Exp. Cell Res
------>paper_name=Enhanced Adhesion of Monocyte via Reverse Signaling Triggered by Decoy Receptor 3 (DcR3)
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------>fullAbstract=Decoy receptor 3 (DcR3), a newly identified soluble protein belonging to the tumor necrosis factor receptor (TNFR) superfamily, is a receptor for Fas ligand (FasL), LIGHT and TL1A. It has been demonstrated that DcR3 is frequently overexpressed by malignant tumors arising from lung, gastrointestinal tract, neuronal glia and virus-associated leukemia. Recently, we demonstrated that DcR3 is able to modulate the differentiation and activation of dendritic cells (DCs), and that DcR3-treated DCs skew naive T cell differentiation towards a Th2 phenotype. In this study, we further demonstrate that DcR3 is able to induce actin reorganization and enhance the adhesion of monocytes and THP-1 cells by activating multiple signaling molecules, such as protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), focal adhesion kinase (FAK) and Src kinases. This provides the first evidence that the soluble DcR3, like other immobilized members of TNFR superfamily, is able to trigger ~reverse signaling~ to modulate cell function.
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------>authors2=Lin WW
------>authors3=Tsao WC
------>authors4=Hsu TL
------>authors5=Chang YC
------>authors6=Hsiao HW,Chiu AW,Chio CC, Hsieh SL
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------>authors=Hsu MJ
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------>updateTitle=Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3.
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------>publish_year=2004
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z