| Hsu MJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.695 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=shiemin ------>insert_bywho=aspirin ------>Jurnal_Rank=34.1 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=E1300 ------>insert_date=20081124 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=450 ------>journal_name=Exp. Cell Res ------>paper_name=Enhanced Adhesion of Monocyte via Reverse Signaling Triggered by Decoy Receptor 3 (DcR3) ------>confirm_date=20081202 ------>tch_id=095032 ------>pmid=14697332 ------>page1= ------>fullAbstract=Decoy receptor 3 (DcR3), a newly identified soluble protein belonging to the tumor necrosis factor receptor (TNFR) superfamily, is a receptor for Fas ligand (FasL), LIGHT and TL1A. It has been demonstrated that DcR3 is frequently overexpressed by malignant tumors arising from lung, gastrointestinal tract, neuronal glia and virus-associated leukemia. Recently, we demonstrated that DcR3 is able to modulate the differentiation and activation of dendritic cells (DCs), and that DcR3-treated DCs skew naive T cell differentiation towards a Th2 phenotype. In this study, we further demonstrate that DcR3 is able to induce actin reorganization and enhance the adhesion of monocytes and THP-1 cells by activating multiple signaling molecules, such as protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), focal adhesion kinase (FAK) and Src kinases. This provides the first evidence that the soluble DcR3, like other immobilized members of TNFR superfamily, is able to trigger ~reverse signaling~ to modulate cell function. ------>tmu_sno=None ------>sno=19801 ------>authors2=Lin WW ------>authors3=Tsao WC ------>authors4=Hsu TL ------>authors5=Chang YC ------>authors6=Hsiao HW,Chiu AW,Chio CC, Hsieh SL ------>authors6_c= ------>authors=Hsu MJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=1 |